hrp0082p1-d2-27 | Autoimmune Endocrine Disease | ESPE2014

Late Endocrine Effects Despite Reduced Intensity Chemotherapy for Bone Marrow Transplantation in Children

Howell Jonathan , Myers Kasiani , Lane Adam , Wallace Gregory , Jodele Sonata , Rose Susan

Background: Bone marrow transplantation (BMT) is known to affect endocrine function, most commonly causing primary hypothyroidism and hypogonadism in children. Newer reduced intensity conditioning (RIC) uses less myeloablative chemotherapy and no irradiation. Our study goal was to evaluate endocrine effects at 1 year post BMT in pediatric patients who received RIC.Methods: Retrospective, IRB-approved chart review was performed on 121 patients (44 females...